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Rotavirus vaccine side effects can include intussusception (bowel blockage that may cause severe intestinal damage), Kawasaki syndrome (an autoimmune response with high fever, inflammation of the blood vessels, swelling in the hands and feet, and peeling skin), severe allergic reactions, severe swelling, stomach pain, fevers, vomiting or nausea, and gastrointestinal bleeding.
Rotavirus is the leading cause of the disease acute gastroenteritis, which causes severe vomiting and diarrhea. It is responsible for more than 500,000 infant deaths worldwide, however in the United States, deaths are rare.